Tokimeki Memorial Girl's Side: 2nd Kiss is the 2006 sequel to Tokimeki Memorial Girl's Side and the fifth main game in Konami's Tokimeki Memorial dating sim series. An enhanced port to the Nintendo DS featuring additional content and titled Tokimeki Memorial Girl's Side: 2nd Season was released in 2008.
It was the final game in the Tokimeki Memorial series to be released on the PlayStation 2, as well as the final console game to date: All subsequent games have been on the Nintendo DS and PlayStation Portable. A Nintendo Switch version titled Tokimeki Memorial Girl's Side: 2nd Season for Nintendo Switch was released on February 14, 2024.
Tokimeki Memorial Girl's Side: 2nd Kiss features the return of two voice actors who have appeared in the previous Tokimeki Memorial games. Yuji Ueda plays Motoharu Masaki in this game and had previously played Yoshio Saotome in the first Tokimeki Memorial game. His character was so popular that he was the only male character to get an album CD prior to the Tokimeki Memorial Girl's Side series. Kenji Nojima plays Kazuyuki Akagi and had previously played Junichirou Hokari in Tokimeki Memorial 2.