The gameplay revolves around fighting a series of CPU-controlled monsters, using one of three selectable characters. It works much like a regular fighting game, with three attack buttons and special moves done with motion inputs. The plot centers on the Ultimate Task Force, a group of heroes who must fight the monsters created by the Happy Droppers, before taking the fight into the Happy Droppers's skull-shaped flying fortress. Quite a few of the enemy monsters are based on staple Gradius enemies and bosses.
- Kotetsu: A martial artist from Japan, and the game's balanced-type character.
- Anne: A fighter from England, and the fastest character.
- Eagle: A wrestler from USA, and the strongest character.
- Dragon: A elemental-changing wyrm-type dragon based on the Intruder from Salamander. His stage is a cave in Norway.
- Fungus/Slime: A shape-shifting slime monster. His stage is a grotto on the Bermuda Triangle.
- Centaur: A red centaur with golden armor. His stage in a temple on Iraq.
- Diablo/Furaiki: A raijin/storm demon. His stage is a pagoda on China.
- Moai: A large Easter Island statue based on the Moai from Gradius. His stage is a underground temple in Brazil.
- Brainy/Golem: A giant floating brain with arms and a single eye, based on the Golem from Salamander. His stage is a cave on Kenya.
- Ducker: A bipedal robot piloted by Mr. Chin, based on the Duckers from Gradius.
- Robo-Ape/Mecha Gorilla: A gorilla-shaped robot piloted by Garuga.
- Cosmic Tank/Happy Buster Ace: A robotic floating chair with a claw and drill piloted by Happy.
- Kotetsu makes a cameo in Let's Attack Crazy Cross as a transformation used by Ryo on his 5+ chain attack.
- Kotetsu and Anne make a brief cameo in the interactive game TwinBee PARADISE in Donburi Shima.
- Anne makes an appearance as a photo in the puzzle game Pixel Puzzle Collection.
- The manga based on the video game titled Kyukyoku Sentai Dadandarn, published in Gamest Comics and created by Reiichi Ito.
- The theme from the Brainy fight is a remix of "Poison of Snake", while the theme from the Moai fight is a remix of "The Old Stone Age".
- On the final stage, the lyrical song "Fight! Dadandarn" plays in the background. This song is sung by Masato Shimon, who is also known for singing the openings to multiple anime, such as Gatchaman and Machine Robo, and several Super Sentai themes.
- While this version has a single vocal part followed by an instrumental portion, a full-lyrical version was released on the 10th Anniversary Konami Label Theme Song Collection, along with many other Konami songs.
- Furthermore, the ending theme also had a lyrical incarnation. "We Are Dadandarn!" is performed by Hironobu Kageyama, who is most famous for singing Dragon Ball Z's two openings: Cha-La Head-Cha-La and We Gotta Power, as well as themes for various Dragon Ball Z games and media.